Kategorien: Organic Chemistry (>> Bio), Medicinal Chemistry >> Natural Products
The Organic Chemistry of Biological Pathways
John McMurry, Tadhg Begley
Gebunden, 490 Seiten
1. Auflage - 2005
ISBN: 0-9747077-1-6
Roberts & Company Publishers
Beschreibung
Chemistry of Biological Pathways provides a contemporary and authoritative treatment of the molecular logic of the chemistry of life... The authors have chosen to organize the text not by organic reaction type but by metabolic pathway. Doing so allows them to explain not only the chemistry of any given step but also the molecular logic of the entire pathway. Readers thus gain a deeper understanding of how and why the organic molecules of life undergo their sequential transformations and interconversions. To integrate the information from earlier chapters, as well as tie in traditional modes of organic reaction classification, the authors conclude with a summary chapter of the most common reaction types encountered in metabolism.
--- from the Foreword by Christopher T. Walsh, Harvard University
Besprechung
Over the past few years, X-ray crystal structures of enzymes and
molecular modeling of enzyme-substrate complexes have revolutionized
biochemistry, the science of the chemical processes in living systems.
While in earlier times the organization of proteins and the structure of
DNA were of interest, and the metabolic cycles and the participating
enzymes were described, the processes that occur between enzymes and
substrates have increasingly claimed the center of attention.
John McMurry and Tadhg Begley have authored an interdisciplinary
presentation that includes a wealth of information. From the most
important organic chemical reaction types that play a role in enzymatic
transformations, through a variety of biomolecules and treatments of
stereochemistry, all the way to specific metabolic reactions, these
authors offer readily understandable mechanistic explanations, e.g. of
the biosynthesis of amino acids and the degradation of sugars. The
strong suit of “The Organic Chemistry of Biological Pathways” lies in
its detailed treatment of metabolic reactions, which has been done
extremely well. The language of the text is easy to understand, the
schemes have been created with care and attention to detail, and the
reader’s grasp of this knowledge can be solidified by working through a
broad range of exercises. Moreover, the selection of current literature
citations makes this a valuable reference work.
Students of chemistry will thus learn the mechanisms of organic
chemistry in the context of interesting metabolic reactions; they can
then apply this knowledge themselves in the exercises and obtain a good
overview of important natural products while doing so. With the detailed
treatment of mechanisms provided here, the future chemist will be
equipped with the fundamentals needed for further study. Considering the
potential impact it can have on one’s later research in the fields of
biochemistry, medicinal chemistry or in the development of catalysts for
the more specific transformation of substrates, the purchase of the book
is money well spent. “The Organic Chemistry of Biological Pathways” is
an excellent supplement to the chemistry student’s textbooks for organic
chemistry or biochemistry, since this work is of benefit to both fields
of endeavor.
Content:
1 Common Mechanisms in Biological Chemistry
2 Biomolecules
3 Lipid Metabolism
4 Carbohydrate Metabolism
5 Amino Acid Metabolism
6 Nucleotide Metabolism
7 Biosynthesis of Some Natural Products
8 A Summary of Biological Transformations
Appendixes
A. Visualizing Protein Structures Using the Swiss PDB Viewer
B. Using the KEGG and BRENDA Databases
C. Answers to End-of-Chapter Problems
D. Abbreviations Used in This Book